United States

In the United States, millions of people depend on compounded medicines to live normal, productive, healthy lives. Their first-hand stories speak directly to the power of this important therapy. As the FDA considers removing access to certain medicines like compounded hormones, their voices must be part of the conversation.

5222 result(s)
Jane C.
Story Image 04.13.2021

“Through compounded bioidential hormone prescriptions, I am a...”

Ellen T.
Story Image 04.13.2021

“I was never able to take birth control pills or Rx hormone r...”

Alisa B.
Story Image 04.13.2021

“I'm not going to sugar coat this- for medical reasons and to...”

Joan O.
Story Image 04.13.2021

“I've been using the compound HRT for MANY years. I started w...”

Kathy W.
Story Image 04.13.2021

“I started experiencing pre-menopausal symptoms after a tubal...”

pam W.
Story Image 04.13.2021

“I am able to do all physical activity and work etc. due to t...”

Lori Y.
Story Image 04.13.2021

“It has been the best thing to happen to me. After my hystere...”

Hilary H.
Story Image 04.13.2021

“Without the opportunity to use compounded hormone therapy, m...”

Roxane A.
Story Image 04.13.2021

“cBHT has made a world of difference in the quality of my lif...”

VICKI S.
Story Image 04.13.2021

“Estrogen based cancer is presented in my sister. My doctor d...”

Tina A.
Story Image 04.13.2021

“I was struggling with several issues that are common with me...”

Salli K.
Story Image 04.13.2021

“cBHT makes me feel great...and normal! It totally eliminates...”

Lorretta W.
Story Image 04.13.2021

“These products are amazing and have basically made my life a...”

Jennifer P.
Story Image 04.13.2021

“For me, this therapy has help me to subside the side effects...”

Amy S.
Story Image 04.13.2021

“I CAN SLEEP! I have had hormone issues since the age of 32. ...”

janice B.
Story Image 04.13.2021

“I tried all of the HRT available in 1995 after a total hyste...”

Caren H.
Story Image 04.13.2021

“The compound gave me back my life! Menopause affected me in ...”

Allyson V.
Story Image 04.13.2021

“Bioidentical progesterone supplements have allowed me to car...”

WILLIAM Y.
Story Image 04.13.2021

“I was tested for my testosterone levels by my urologist. My ...”

Pamela B.
Story Image 04.13.2021

“It has increased my sexual desire and activity. It has givin...”

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Image
04.13.2021
Jane C.
Kansas Lenexa

“Through compounded bioidential hormone prescriptions, I am a...”

Through compounded bioidential hormone prescriptions, I am able to work with my doctor and get the exact dose that best fits my needs. I believe they have kept me feeling younger and more active than many women my age, without the side effects caused by traditional hormone replacement. I currently use a bioidential hormone cream as well as a capsule for Progesterone. My insurance plan used to cover these, but since the ACA forced my prior insurance carrier to drop individual plans, I now have to pay for these prescriptions out of pocket. They are not covered by insurance plans, which makes no sense as I feel they are keeping my healthier.
Image
04.13.2021
Ellen T.
Kansas Paola

“I was never able to take birth control pills or Rx hormone r...”

I was never able to take birth control pills or Rx hormone replacement due to severe side effects. Compounded bioidentical hormone therapy has been the only method that has improved my quality of life in relation to hot flashes, mood swings, better sleep etc. cBHT has been life changing for me.
Image
04.13.2021
Alisa B.
Kansas SHAWNEE

“I'm not going to sugar coat this- for medical reasons and to...”

I'm not going to sugar coat this- for medical reasons and to prevent cancer, I had no choice but to remove my female organs...all of them. I was made to believe that since I'm 47 and likely perimenopausal, I shouldn't suffer any ill effects hormonally. Gentlemen, this is incorrect and I have suffered greatly. I wouldn't wish these physical and mental effects on my worst enemy. I have suffered from so many horrendous night sweats (about 15 each night) and each lasts about 10 minutes or more. Tell me how a woman is suppose to function when she's not able to sleep due to night sweats? The hot flashes during the day are bad enough. My family wanted me out of the house at night because they all just about froze to death. My hair started falling out and still is. And my mental capacity and attitude were always kind and loving...it seems I'm bitchy to just about everyone and I seem to have lost my mothering compassion. Honestly, I'd rather be dead than to be without cBHRT because it has saved mine and my family and coworkers lives as well.
Image
04.13.2021
Joan O.
Kansas Leavenworth

“I've been using the compound HRT for MANY years. I started w...”

I've been using the compound HRT for MANY years. I started with the troche, but the small private pharmacy in Leavenworth closed. My OBGYN suggested the vaginal cream for its lower dosage and personal balance. (I had to find a compound pharmacy in Kansas City). I feel it's kept me physically the same as I was before menopause, in ALL respects. I feel good, and most notably, my skin is moist and young. My body has not 'dried up', as they say. I'm now 71. My doctor recommended I cut back to just 1/2GM to keep the dosage even safer. I have never had any side effects or problems with this RX...being compounded just for me. Whenever I get the chance and the subject comes up with younger women, I highly recommend this type of HRT from the start, rather than suffering through testing other tablet type solutions. Even a few times when insurance wouldn't cover it, we gladly paid out of pocket...it's priceless! It just logically makes sense to be created individually for each woman, than guessing what 'might' work for all.
Image
04.13.2021
Kathy W.
Kansas Leawood

“I started experiencing pre-menopausal symptoms after a tubal...”

I started experiencing pre-menopausal symptoms after a tubal-ligation. That was a very tumultuous time for our family. My symptoms were very disruptive to our family's dynamic each month. After starting on cBHT, everything stabilized with my symptoms and in our family dynamic. I truly wonder if our family would have stayed intact without my hormone prescription.
Image
04.13.2021
pam W.
Kansas Prairie Village

“I am able to do all physical activity and work etc. due to t...”

I am able to do all physical activity and work etc. due to these hormones After returning from Mayo Clinic, I was unable to function on estrodial and plain estrogen therapy and was placed on compounded hormones which saved my life.
Image
04.13.2021
Lori Y.
Kansas Overland Park

“It has been the best thing to happen to me. After my hystere...”

It has been the best thing to happen to me. After my hysterectomy, I was miserable. Moody, depressed, and my skin looked like I was 80, but I was 38. I had terrible migraines on a regular basis. I had ZERO libido. I didn't find bioidentical HRT until several years after my hysterectomy. This truly has saved my marriage and has changed my way of thinking. I am no longer dealing with depression, migraines, my skin is so much better, and needless to say my libido is back!
Image
04.13.2021
Hilary H.
Kansas Overland Park

“Without the opportunity to use compounded hormone therapy, m...”

Without the opportunity to use compounded hormone therapy, my life would not be the same. I went to my doctor (in fact I went to three doctors) and tried various other drugs....nothing touched the hot flashes and the affect they were having on my ability to sleep and get through the day. Thank goodness for hormone therapy. Restricting this option will NOT be a benefit to women. As it is, I have to pay for it totally out of pocket. It's worth every penny.
Image
04.13.2021
Roxane A.
Kansas Overland Park

“cBHT has made a world of difference in the quality of my lif...”

cBHT has made a world of difference in the quality of my life. No further terrible hot flashes and night sweats. My mood and sleep quality has improved tremendously. I had tried Premarin without any relief and it also made me have nightmares when I did sleep.
Image
04.13.2021
VICKI S.
Kansas LEAWOOD

“Estrogen based cancer is presented in my sister. My doctor d...”

Estrogen based cancer is presented in my sister. My doctor doesn't wants me to take hormone replacement therapy. I have had no issues and the hormone replacement therapy has greatly enhanced my well-being, health and life.
Image
04.13.2021
Tina A.
Kansas Olathe

“I was struggling with several issues that are common with me...”

I was struggling with several issues that are common with menopause. The one that was most disruptive to my life was FOGGY BRAIN. I do hospital EHR software implementation. I need a clear brain at all times and the compounds have kept me working competitively with my millennium peers! Thank you for allowing me to stay focused and working into my sixties! All of the other fixes are definitely a bonus too!
Image
04.13.2021
Salli K.
Kansas Leawood

“cBHT makes me feel great...and normal! It totally eliminates...”

cBHT makes me feel great...and normal! It totally eliminates hot flashes. I read that it slows bone loss in women predisposed to osteoporosis of which I am one. Also, genetically, I am more able to utilize "natural" hormones as opposed to synthetic, non-bioidentical ones because of two genetic mutations of my methylenetetrahydrofolate reductase gene. "mthfr" (C677T).
Image
04.13.2021
Lorretta W.
Kansas GARDNER

“These products are amazing and have basically made my life a...”

These products are amazing and have basically made my life as if I am not menopausal. My husband especially appreciates it!
Image
04.13.2021
Jennifer P.
Kansas Louisburg

“For me, this therapy has help me to subside the side effects...”

For me, this therapy has help me to subside the side effects that I was enduring with menopause. I had several symptoms such as night sweats, waking up drenched, having to change sheets and clothing two to three times week. Hot flashes during the day, vaginal dryness, weight gain, tender breasts, decreased sex drive, etc... You name it, I had it. These troches that I take have been positively a huge asset for me during this time.
Image
04.13.2021
Amy S.
Kansas Shawnee

“I CAN SLEEP! I have had hormone issues since the age of 32. ...”

I CAN SLEEP! I have had hormone issues since the age of 32. I started with replacements at 38.
Image
04.13.2021
janice B.
Kansas Overland Park

“I tried all of the HRT available in 1995 after a total hyste...”

I tried all of the HRT available in 1995 after a total hysterectomy. The side effects were horrible. I was introduced to troches in 1996, then switched to the creme in 2017. I have had no side effects. I am on bi estrogen, progesterone, and testosterone. I cannot live without them!
Image
04.13.2021
Caren H.
Kansas 3540 W 194th Street

“The compound gave me back my life! Menopause affected me in ...”

The compound gave me back my life! Menopause affected me in many negative ways. I used to have a pictorial memory. If I looked twice at a phone number, I had it memorized, which was a wonderful assent in my business. With menopause, I totally lost that ability. I had severe and numerous hot flashes, over 30 a day. I also started having trouble handling the numerous details which used to be a part of my life. I was having difficulty just functioning and coping with ordinary tasks. I tried prescription estrogen replacements such as Premarin. That is the only one I remember by name, though I tried others too, with mixed results. Using bioidentical hormone therapy has worked for me. I stopped having the hot flashes, which were debilitating during my business day. I regained my abiliity to cope with day to day activities, which had become overwhelming with the onset of menopause. I did get back the pictorial memory eventually, as I continued to use the bioidentical hormone therapy. Menopause severely altered my life. Using the bioidentical therapy has allowed me to keep my lifestyle and regain my life.
Image
04.13.2021
Allyson V.
Iowa SPIRIT LAKE

“Bioidentical progesterone supplements have allowed me to car...”

Bioidentical progesterone supplements have allowed me to carry my children to term (my natural progesterone levels do not support pregnancy). Without supplemental bioidentical progesterone, I would have miscarried both of my children. Instead, using hormone support that was prescribed by my doctor to replace the hormones my body doesn't produce on its own, I have two beautiful children who are alive and well today, without the risk of cancers associated with non-bioidentical hormone supplements.
Image
04.13.2021
WILLIAM Y.
Iowa UNDERWOOD

“I was tested for my testosterone levels by my urologist. My ...”

I was tested for my testosterone levels by my urologist. My levels were very low and I had health issues related to that. I was unable to tolerate Androgel due to the alcohol base causing skin rashes. I have also tried Axiron with the same results. Neither of these drugs actually raised my testosterone levels. The drugs were also extremely expensive. $700+ per month and insurance was of no help. My doctor was going to try a long-acting injection which my insurance originally approved but then declined. At this point, my doctor contacted a compounding pharmacy and they stated that they could make me a topically applied cream that would not cause the skin rash issues I have experienced previously. The cream raised my testosterone levels to a point that I started to feel normal again and the cost was only $85 per month. I am 69 and have been using this medication for several years and I strongly feel it has greatly improved my life. To take this type of treatment away from elderly men that need it would be a great disservice to older individuals that need a testosterone treatment to keep their bodies and mental wellbeing at a level that allows us to function normally and enjoy a full life.
Image
04.13.2021
Pamela B.
Iowa Council Bluffs

“It has increased my sexual desire and activity. It has givin...”

It has increased my sexual desire and activity. It has giving me more energy to exercise six days a week. It is help me maintain my weight at a good level. I have had no side effects from taking the hormones for seven or eight years.
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+ Add your story
Story Image Jane C.

“Through compounded bioidential hormone prescriptions, I am a...”

Story Image Ellen T.

“I was never able to take birth control pills or Rx hormone r...”

Story Image Alisa B.

“I'm not going to sugar coat this- for medical reasons and to...”

Story Image Joan O.

“I've been using the compound HRT for MANY years. I started w...”

Story Image Kathy W.

“I started experiencing pre-menopausal symptoms after a tubal...”

Story Image pam W.

“I am able to do all physical activity and work etc. due to t...”

Story Image Lori Y.

“It has been the best thing to happen to me. After my hystere...”

Story Image Hilary H.

“Without the opportunity to use compounded hormone therapy, m...”

Story Image Roxane A.

“cBHT has made a world of difference in the quality of my lif...”

Story Image VICKI S.

“Estrogen based cancer is presented in my sister. My doctor d...”

Story Image Tina A.

“I was struggling with several issues that are common with me...”

Story Image Salli K.

“cBHT makes me feel great...and normal! It totally eliminates...”

Story Image Lorretta W.

“These products are amazing and have basically made my life a...”

Story Image Jennifer P.

“For me, this therapy has help me to subside the side effects...”

Story Image Amy S.

“I CAN SLEEP! I have had hormone issues since the age of 32. ...”

Story Image janice B.

“I tried all of the HRT available in 1995 after a total hyste...”

Story Image Caren H.

“The compound gave me back my life! Menopause affected me in ...”

Story Image Allyson V.

“Bioidentical progesterone supplements have allowed me to car...”

Story Image WILLIAM Y.

“I was tested for my testosterone levels by my urologist. My ...”

Story Image Pamela B.

“It has increased my sexual desire and activity. It has givin...”

Image
04.13.2021
Jane C.
Kansas Lenexa

“Through compounded bioidential hormone prescriptions, I am a...”

Through compounded bioidential hormone prescriptions, I am able to work with my doctor and get the exact dose that best fits my needs. I believe they have kept me feeling younger and more active than many women my age, without the side effects caused by traditional hormone replacement. I currently use a bioidential hormone cream as well as a capsule for Progesterone. My insurance plan used to cover these, but since the ACA forced my prior insurance carrier to drop individual plans, I now have to pay for these prescriptions out of pocket. They are not covered by insurance plans, which makes no sense as I feel they are keeping my healthier.
Image
04.13.2021
Ellen T.
Kansas Paola

“I was never able to take birth control pills or Rx hormone r...”

I was never able to take birth control pills or Rx hormone replacement due to severe side effects. Compounded bioidentical hormone therapy has been the only method that has improved my quality of life in relation to hot flashes, mood swings, better sleep etc. cBHT has been life changing for me.
Image
04.13.2021
Alisa B.
Kansas SHAWNEE

“I'm not going to sugar coat this- for medical reasons and to...”

I'm not going to sugar coat this- for medical reasons and to prevent cancer, I had no choice but to remove my female organs...all of them. I was made to believe that since I'm 47 and likely perimenopausal, I shouldn't suffer any ill effects hormonally. Gentlemen, this is incorrect and I have suffered greatly. I wouldn't wish these physical and mental effects on my worst enemy. I have suffered from so many horrendous night sweats (about 15 each night) and each lasts about 10 minutes or more. Tell me how a woman is suppose to function when she's not able to sleep due to night sweats? The hot flashes during the day are bad enough. My family wanted me out of the house at night because they all just about froze to death. My hair started falling out and still is. And my mental capacity and attitude were always kind and loving...it seems I'm bitchy to just about everyone and I seem to have lost my mothering compassion. Honestly, I'd rather be dead than to be without cBHRT because it has saved mine and my family and coworkers lives as well.
Image
04.13.2021
Joan O.
Kansas Leavenworth

“I've been using the compound HRT for MANY years. I started w...”

I've been using the compound HRT for MANY years. I started with the troche, but the small private pharmacy in Leavenworth closed. My OBGYN suggested the vaginal cream for its lower dosage and personal balance. (I had to find a compound pharmacy in Kansas City). I feel it's kept me physically the same as I was before menopause, in ALL respects. I feel good, and most notably, my skin is moist and young. My body has not 'dried up', as they say. I'm now 71. My doctor recommended I cut back to just 1/2GM to keep the dosage even safer. I have never had any side effects or problems with this RX...being compounded just for me. Whenever I get the chance and the subject comes up with younger women, I highly recommend this type of HRT from the start, rather than suffering through testing other tablet type solutions. Even a few times when insurance wouldn't cover it, we gladly paid out of pocket...it's priceless! It just logically makes sense to be created individually for each woman, than guessing what 'might' work for all.
Image
04.13.2021
Kathy W.
Kansas Leawood

“I started experiencing pre-menopausal symptoms after a tubal...”

I started experiencing pre-menopausal symptoms after a tubal-ligation. That was a very tumultuous time for our family. My symptoms were very disruptive to our family's dynamic each month. After starting on cBHT, everything stabilized with my symptoms and in our family dynamic. I truly wonder if our family would have stayed intact without my hormone prescription.
Image
04.13.2021
pam W.
Kansas Prairie Village

“I am able to do all physical activity and work etc. due to t...”

I am able to do all physical activity and work etc. due to these hormones After returning from Mayo Clinic, I was unable to function on estrodial and plain estrogen therapy and was placed on compounded hormones which saved my life.
Image
04.13.2021
Lori Y.
Kansas Overland Park

“It has been the best thing to happen to me. After my hystere...”

It has been the best thing to happen to me. After my hysterectomy, I was miserable. Moody, depressed, and my skin looked like I was 80, but I was 38. I had terrible migraines on a regular basis. I had ZERO libido. I didn't find bioidentical HRT until several years after my hysterectomy. This truly has saved my marriage and has changed my way of thinking. I am no longer dealing with depression, migraines, my skin is so much better, and needless to say my libido is back!
Image
04.13.2021
Hilary H.
Kansas Overland Park

“Without the opportunity to use compounded hormone therapy, m...”

Without the opportunity to use compounded hormone therapy, my life would not be the same. I went to my doctor (in fact I went to three doctors) and tried various other drugs....nothing touched the hot flashes and the affect they were having on my ability to sleep and get through the day. Thank goodness for hormone therapy. Restricting this option will NOT be a benefit to women. As it is, I have to pay for it totally out of pocket. It's worth every penny.
Image
04.13.2021
Roxane A.
Kansas Overland Park

“cBHT has made a world of difference in the quality of my lif...”

cBHT has made a world of difference in the quality of my life. No further terrible hot flashes and night sweats. My mood and sleep quality has improved tremendously. I had tried Premarin without any relief and it also made me have nightmares when I did sleep.
Image
04.13.2021
VICKI S.
Kansas LEAWOOD

“Estrogen based cancer is presented in my sister. My doctor d...”

Estrogen based cancer is presented in my sister. My doctor doesn't wants me to take hormone replacement therapy. I have had no issues and the hormone replacement therapy has greatly enhanced my well-being, health and life.
Image
04.13.2021
Tina A.
Kansas Olathe

“I was struggling with several issues that are common with me...”

I was struggling with several issues that are common with menopause. The one that was most disruptive to my life was FOGGY BRAIN. I do hospital EHR software implementation. I need a clear brain at all times and the compounds have kept me working competitively with my millennium peers! Thank you for allowing me to stay focused and working into my sixties! All of the other fixes are definitely a bonus too!
Image
04.13.2021
Salli K.
Kansas Leawood

“cBHT makes me feel great...and normal! It totally eliminates...”

cBHT makes me feel great...and normal! It totally eliminates hot flashes. I read that it slows bone loss in women predisposed to osteoporosis of which I am one. Also, genetically, I am more able to utilize "natural" hormones as opposed to synthetic, non-bioidentical ones because of two genetic mutations of my methylenetetrahydrofolate reductase gene. "mthfr" (C677T).
Image
04.13.2021
Lorretta W.
Kansas GARDNER

“These products are amazing and have basically made my life a...”

These products are amazing and have basically made my life as if I am not menopausal. My husband especially appreciates it!
Image
04.13.2021
Jennifer P.
Kansas Louisburg

“For me, this therapy has help me to subside the side effects...”

For me, this therapy has help me to subside the side effects that I was enduring with menopause. I had several symptoms such as night sweats, waking up drenched, having to change sheets and clothing two to three times week. Hot flashes during the day, vaginal dryness, weight gain, tender breasts, decreased sex drive, etc... You name it, I had it. These troches that I take have been positively a huge asset for me during this time.
Image
04.13.2021
Amy S.
Kansas Shawnee

“I CAN SLEEP! I have had hormone issues since the age of 32. ...”

I CAN SLEEP! I have had hormone issues since the age of 32. I started with replacements at 38.
Image
04.13.2021
janice B.
Kansas Overland Park

“I tried all of the HRT available in 1995 after a total hyste...”

I tried all of the HRT available in 1995 after a total hysterectomy. The side effects were horrible. I was introduced to troches in 1996, then switched to the creme in 2017. I have had no side effects. I am on bi estrogen, progesterone, and testosterone. I cannot live without them!
Image
04.13.2021
Caren H.
Kansas 3540 W 194th Street

“The compound gave me back my life! Menopause affected me in ...”

The compound gave me back my life! Menopause affected me in many negative ways. I used to have a pictorial memory. If I looked twice at a phone number, I had it memorized, which was a wonderful assent in my business. With menopause, I totally lost that ability. I had severe and numerous hot flashes, over 30 a day. I also started having trouble handling the numerous details which used to be a part of my life. I was having difficulty just functioning and coping with ordinary tasks. I tried prescription estrogen replacements such as Premarin. That is the only one I remember by name, though I tried others too, with mixed results. Using bioidentical hormone therapy has worked for me. I stopped having the hot flashes, which were debilitating during my business day. I regained my abiliity to cope with day to day activities, which had become overwhelming with the onset of menopause. I did get back the pictorial memory eventually, as I continued to use the bioidentical hormone therapy. Menopause severely altered my life. Using the bioidentical therapy has allowed me to keep my lifestyle and regain my life.
Image
04.13.2021
Allyson V.
Iowa SPIRIT LAKE

“Bioidentical progesterone supplements have allowed me to car...”

Bioidentical progesterone supplements have allowed me to carry my children to term (my natural progesterone levels do not support pregnancy). Without supplemental bioidentical progesterone, I would have miscarried both of my children. Instead, using hormone support that was prescribed by my doctor to replace the hormones my body doesn't produce on its own, I have two beautiful children who are alive and well today, without the risk of cancers associated with non-bioidentical hormone supplements.
Image
04.13.2021
WILLIAM Y.
Iowa UNDERWOOD

“I was tested for my testosterone levels by my urologist. My ...”

I was tested for my testosterone levels by my urologist. My levels were very low and I had health issues related to that. I was unable to tolerate Androgel due to the alcohol base causing skin rashes. I have also tried Axiron with the same results. Neither of these drugs actually raised my testosterone levels. The drugs were also extremely expensive. $700+ per month and insurance was of no help. My doctor was going to try a long-acting injection which my insurance originally approved but then declined. At this point, my doctor contacted a compounding pharmacy and they stated that they could make me a topically applied cream that would not cause the skin rash issues I have experienced previously. The cream raised my testosterone levels to a point that I started to feel normal again and the cost was only $85 per month. I am 69 and have been using this medication for several years and I strongly feel it has greatly improved my life. To take this type of treatment away from elderly men that need it would be a great disservice to older individuals that need a testosterone treatment to keep their bodies and mental wellbeing at a level that allows us to function normally and enjoy a full life.
Image
04.13.2021
Pamela B.
Iowa Council Bluffs

“It has increased my sexual desire and activity. It has givin...”

It has increased my sexual desire and activity. It has giving me more energy to exercise six days a week. It is help me maintain my weight at a good level. I have had no side effects from taking the hormones for seven or eight years.
Image
Image

Hear their stories, in their own words. Protect their access to compounded hormones.

On this page, we can only touch on the data that demonstrates the importance of compounded hormones to the lives of millions of women in this country. While the decision to take this vital therapy from patients and physicians might be profitable for the big pharmaceutical companies, it will be disastrous for the millions of patients that those same pharmaceutical companies cannot serve!

We encourage the appropriate committees in both the House and Senate to hold hearings on this critical issue.

Preserve compounded hormones.

Explore our interactive map that demonstrates the importance of compounded hormones to patients all across the country. Filter these first-hand accounts by state to see just how vital compounded hormones are.

Explore our interactive map that demonstrates the importance of compounded hormones to patients all across the country. Filter these first-hand accounts by state to see just how vital compounded hormones are.

No. of testimonials
5222