I was in the worst hormone hell with 40 extra lbs on me, severe perimenopause, severe PMS and sleep apnea (77 episodes of not breathing overnight). My gynocologest put me into estrogen dominance twice. A saliva test showed that I had so much in my system which was causing all the negative symptoms. It took a long time to get a good balance, but at 69 and 140 lbs, plus teaching pilates for 17 years, I'm doing great. I take my troche every night without fail along with my capsule of progesterone. PLEASE DON'T LET THEM STOP MAKING COMPOUNDED HORMONES. I wouldn't last long without them. I want my "quality of life" to remain the same.