I started on Progesterone back in 2004 because of PMS. I increased it as I approached menopause. It helped me with emotional issues and I drifted through menopause smoothly. I had ups and downs, then knew I needed estriol, then testosterone. I could feel the difference in a couple days with going on estriol as far as depression and moods. Same with testosterone. My sisters had a hard time with menopause and bled so bad they were bedridden. I did not have that at all. I had a period end of February 2007 and two weeks later one more and was done. NO issues. I tell you the only time i had issues when I was starting menopause and didnt know it, and i was being cheap and not getting Progesterone every month. I skipped and the phamacist i had here in town before i went to mail order, told me don't increase it, you are not buying it every month, you are every other month. No wonder I was an emotional mess. I started being consistant taking it, and then I balanced out. I will not be without it. And now I pay for all three hormones out of my own pocket because insurance won't pay. I can get the patch or pills, but I feel this is safer. Thank God for these compounding hormones. If I pay for this myself, then what is the issue?