I started bioidentical hormones at age 44 shortly after the birth of my fourth child. I felt a difference shortly after starting. The best evidence I have of how well they work is from the two times I had to stop using them. The first time was when my husband lost his job. I was a stay at home mom so finances were tight. I decided to save money and stop the hormones. After a couple of months, my husband offered to replace my old computer. That evening I told him I would rather get back on my hormones. I went for an appointment later that week and was able to restart the treatment. Shortly after restarting, I felt the best I had in probably my whole life; like when I was a young woman. The second time I stopped was when I had to have a breast biopsy. The company line is that hormones cause cancer. I stopped. Going in to my follow up appointment after surgery I talked with my surgeon about how I was feeling. I told her I may not get cancer but I'm going to go crazy. My mood was all over the place. I was a mess. I spoke with a cancer specialist and we agreed my hormones were not a huge risk for me. I restarted and felt the positive affects almost immediately. I have many friends who do not use the hormones that I do. They do not sleep, their skin is awful, they are hot flashing, they are moody. I am so thankful, and so is my husband, that I am on these hormones that have me living a normal life. I feel great, I sleep great, and I have never had a hot flash. I recommend these to everyone.