I had a complete hysterectomy at 42 and tried using prescription estrogen patches and did not have good results. I was tired, had hot flashes and was feeling off. I told the doctor I felt different and not like myself and when they tested my hormones, I wasn't getting enough from the patches. I was also not pleased with my doctor and her attitude.
I switched doctors to one that prescribes compounds. I was very nervous but after a few months the I could see the difference. No more hot flashes, I felt more balanced and just overall more normal. I can't imagine how long it would take to figure out what combination of drugs would produce the same results.