When in my mid-40's, started going through a change of life. Started out with day sweats which soon turned into awful night sweats and no sleep...I was miserable. My PA at the time was hesitant to put me on hormone replacement BUT after my levels got bad enough she prescribed bio-identical hormone replacement therapy (BHRT). At that time, there was only one or perhaps two compounding pharmacies in town but was fortunate enough to find one that worked with my PA to compound a formula that provided relief. Hormone levels had to be checked often to make sure my levels were where they needed to be but that was so much better than being miserable 24/7. I'm still on BHRT and hope to remain on them until such time as they are no longer necessary to regulate my erratic hormone levels.