At the age of 40, I was diagnosed with Hashimoto's disease. I was severely hypothyroid. Within two weeks of starting Synthroid I developed severe anxiety. This was treated with high doses of two psychotropic drugs for many years. About four years ago I found a doctor who was willing to prescribe compounded T3/T4. He also was very knowledgeable of how other female hormones are affected by the thyroid. After testing he started me on estrogen and compounded progesterone. Within a matter of a few short weeks my anxiety was gone. Shortly after I was able to begin tapering off the psychotropic drugs. (I had been treated with hormones previously but had been prescribed a synthetic progestin. I had very negative side effects with this.)