In 2018 my Total and Free Testosterone had plummeted from nearly 450/57 to 45/.9. My E2 was 65. I was sexless, depressed and extremely low energy. I was dondepressed I was considering suicide. After a blood draw my Doctor asked me if I wanted to do something about my Low (Hypogonadism) testosterone. I said yes. He started me on self injections and essentially saved my life. If the compounding pharmaciesvare shut down it will drive the price of testosterone up and limit my therapy to one ester not the compound that makes me feel better.