When the women's study of Premarin declared that Premarin was harmful, I went off it. I then had hot flashes every 35 minutes day and night. After many tries, I am on a bioidentical Biest (not the usual triest) compounded with other hormones including much needed DHEA. The biest formula has stopped my hot flashes and left me feeling well after several years of misery. DO NOT take this valuable tool away from me. I need the precise dosage I am getting now.