When I was premenopausal, I read up on bioidentical hormones versus premarin. I talked to my OBGYN about this and he shot me down big time and told me not to believe everything I read. I never went back and found an OBGYN that was open to bioidentical. I have been using for years. I take three different kinds, and pay 100 percent for it, although I have good health coverage, it does not cover the cost. Please do not take my right away to use this.