When I lost all my natural hormones due to surgery, my life changed dramatically, for the worse! I had extreme mood swings, severe hot flashes, and could never get a good night's sleep. I would finally fall asleep for 30 minutes, and then wake suddenly with my night clothes wringing wet! I gained 30 pounds, even though I did not increase my calories, and have spent the last 60 years living and working on a family farm. Talk about experiencing negative symptoms, boy did I. Of course I was depressed. Thank heavens my gynecologist listened and prescribed bioidentical hormones, specifically for my individual needs, as each person is indeed different. These hormones changed my life and helped me feel "normal" again.