When I had symptoms from menopause, I went to my gynecologist and thank goodness she tested my hormones. She said if I had gone to a regular doctor, they would have said I needed estrogen. But, my estrogen levels were so high she said if I had taken it I would have had a nervous breakdown, because I was so stressed and depressed. She saw my progesterone levels were extremely low and also testosterone was low. She was one of a few doctors in the area doing hormone replacement. I started progesterone cream and testosterone cream and within three weeks I started to feel like myself again. No depression or sadness or anxiety. I have been using these two creams for 10 years. I have a new doctor and he tests me every year and adjusts the dose if needed. These hormone creams have saved my sanity. I will continue to use them.