Topical testosterone dramatically improved muscle tone after being on a corticosteroid too long, which caused muscles to shrivel up. I have been on oral and topical estrodiol improved memory, decreased bladder leakage, and increased my energy and is necessary for good bone density. Oral slow release progesterone raised my serum blood levels, improved sleep whereas other brands did not, allowing my physician to balance the sex hormones. Also other brands caused significant side effects such as headaches, joint pain, bronchial constriction, and gastritis. Hormones have improved my life.