To me, it is important to use "natural" instead of synthetic hormones. These hormones match what my body was used to producing. They are tailored for ME! I have no side effects. Every woman has different hormone levels. For me, I had a complete hysterectomy over 30 years ago and I feel balanced. NO night sweats, NO hot flashes, and research shows these bypass my liver. I do not want my whole well-being to change.