There has been no downside to cBHT. I have only positives to report. In the beginning it was very pleasant to not be as affected by daily hormonal fluctuations. I was still menstruating, and had ridiculous cycles. In fact my whole life was ridiculous hormonal fluctuations, and the pelvic pain was unbearable at times. None of my friends, coworkers or family members had symptoms like mine. I will forever be grateful to the physician who prescribed cBHT and the compounding pharmacy. I see no reason for me not to continue with cBHT. I cannot imagine there is a good reason for the FDA to be messing around with the quality of my life.