The twice-weekly applications of estradiol have had a tremendous impact on my overall sense of well-being and energy levels. The five nights per week that I do not use estradiol, I have my sleep interrupted 5 to 6 times to empty my bladder. By comparison, the two nights that I apply the cream I'm interrupted once or at most two times to empty my bladder. A restful night's sleep is very important to my physical and mental functioning. I consider the compound cream to be of utmost importance to my health.