The most significant effect of bioidentical progesterone has been improvement in sleep, which has led to me feeling calmer and looking better with more energy to exercise, to think more clearly and overall take better care of myself my household and husband. A huge boost to my self-esteem. An unexpected side benefit has also been healthier stronger nails. Being able to customize the dosage also helped me control acne and irritability, a side effect that emerged with too high a dosage. It took tinkering with three different dosages to find right one for me, so I could still get the benefits without the side effects.