The creams did not work for me. But the implantable pellets, taken along with the progesterone pills created by a compound pharmacy, were a complete game changer. My hot flashes have totally gone away. I have more energy, sex drive, I think more clearly, and more. I highly recommend the implantable pellets, along with the progesterone pills from a compound pharmacy. I hope that the FDA does not restrict compounded hormone replacement therapy!