The brand name vaginal cream prescribed to me, and then the generic cream, irritated my external and internal vagina. They gave me yeast infections- up to six or more per year. The compounded gel I take does not irritate me or given me any yeast infections. I have been using the gel for over a year now. My urinary stress incontinence is 95 percent better! Compounded Estriol gel has been a life changer post-menopausal.