After suffering severe symptoms for several years from a sudden drop in hormones forcing menopause after a car accident I decided to try bi-identical HRT. My mom had used RX artificial hormone replacement for years after a hysterectomy at 35 years of age only later to have a heart attack at 48 and breast cancer, (non-smoker, non-drinker, very active person). I will NEVER use artificial hormones. Bio-identical has given me my life back. Strong bones, healthy tissue, no HOT flashes, or mood swings. I feel great at 59 yers old! I can't imagine life my life without it. My gynecologist says it is serving me well.