Prior to being prescribed custom-compounded HRT, my doctor had me try some of the Big Pharma products, which did not help me at all. I continued having hot flashes and sweats that came on without notice at any time of the day or night. Sometimes I'd get so hot I'd get sick to my stomach, and my sleep was totally disrupted every night. It is hard to feel good when you're not able to get quality sleep. My Durham, NC compounding pharmacist and my gynocologist worked together to determine the right prescription for me, and continue to monitor things. I cannot overstate what a difference bioidentical HRT has made in the positive quality of my health and life, and I shudder to think how I would feel without it. I am genuinely sorry for communities without a compounding pharmacy, especially for women of menopausal age. I tell every woman I know what a fabulous difference bioidentical HRT has made in my life. I am so grateful for this service!