Because balance is the whole issue. That's why just estrogen alone has bad results in clinical trials. And it's why anyone or two hormones replaced can look like hormone therapy isn't good for us, when in fact, keeping our hormones in balance is the most important thing we can do to prevent age-related illness and decline. Bioidentical compounded hormones are a literal life-saver for menopausal women and all those who suffer from hormonal imbalance. Don't take that away from us over flawed or incomplete studies.