I have been using natural hormones since I was 54 and now 75 years old. I have excellent health and use no pharmaceutical drugs. When I tell them how old I am, many people can't believe that I am 75. I have had no adverse reaction to the natural hormones as opposed to my brother-in-law who took pharmaceutical testosterone and almost died because it thickened his blood so much. I know other people who are taking natural hormones and none of them have had any adverse reaction.