My experience with FDA approved hormone replacements versus compounded, is night and day. The compounded products are all natural, they work without side effects, and can be callibrated to what your body needs, as indicated by regular testing. I now eat a plant-based diet and now have an even better understanding of how the body is able to assimilate natural ingredients that are bioidentical. I am currently using an estrogen cream, with the dosing adjusted by how many clicks, based on test results, and a progesterone troche. The Premarin product, FDA approved, which was first pushed on women my age, proved to be dangerous. I have been using compounded products for probably 25 years, with peace of mind.