I had a surgical brought on menopause in my mid 20's. I do have one son born in 1972. I was 21 years of age. Premarin .625 mgs daily for years . Severe headaches I did not understand . Dr at time discussed hormone coumpound. Although he was not a gynecologist, but an allergy and immunologist.and treated the thyroid.also. He also wrote natural compound medicines too. So I began taking the better form of estrogen . It greatly decreased the head aches . I have been on it for MANY years. It really does me a world of good. I am sensitive to many other medications. Combined with thyroid treatment and the small dose estrogen, something just blended and it is my combination that is taylor made just for me. I am now 68. This works and I am sure it is a blessing to other women at whatever their individual needs are. The other great benefit is the cost is quite economical and affordable. Thank you for caring.