Hot flashes were making me incredibly sick, and interfering with sleep every night. Until HRT that is! Not to mention the complete difference they make for sexual intimacy in my marriage. My doctor has always monitored me to make sure I never exceed the required healthy levels for my age, and I've never developed any complications or negative side effects. I honestly don't know of any doctor or compounding pharmacy that prescribes hormonal replacement irresponsibly. However, I believe it would be completely irresponsible to take such a life allowing therapy away from patients.