I’ve been using bio-identical hormones for 14 years and it was life-changing for me. I had hot flashes and body flushing that happened every 20 minutes, 24 hours a day, 7 days a week. I could not sleep and it was affecting my work and my relationships. I would never go back. I will never use the synthetic version primarily because they must be broken down in the liver. The cream I use is absorbed through my skin sidestepping my liver. Better for my body.