As I neared 50 and noticed pre-menopausal symptoms - hot flashes, difficulty sleeping, joint aches, mood swings, dry skin, etc. I looked for options. I began with Estrogen, Progesterone, Testosterone. Then in a few years, I added Thyroid NR. I supplement with vitamins including B12, K, D, and Glutamine. I feel 1000% better physically, mentally, socially. I have kept muscle mass, taken up golf, and slept 8 hours a night without interruption. My family notices a dramatic difference in my overall outlook. I am now 61 and don't plan to change my health routine. I have had no serious illness in more than a decade.