It's like night and day! Insomnia, brain fog, anxiety, anger/irritation, inability to control body temp (hot flashes to freezing cold) ALL have gone away. I simply feel NORMAL! I was taken off all hormones for a month when I had a breast cancer scare and the lab lost my results. ALL those symptoms came back and now that I'm menopausal, there was a new symptom: increased belly fat and I eat low carb and workout hard and lead a very active lifestyle. Once I restarted the hormones (no breast cancer), ALL those symptoms went away. Plus they're a safer alternative to synthetic hormones which, I might add, don't have the combination I need!