It has significantly helped my bones, my skin, my tissue, and my mood. My marriage would not be the same without my bioidentical hormone therapy. I look healthier than a lot of 66 year old women. My husband is also taking bioidentical homones. Why would anyone want to take hormones that are not the normal chemical configuration that our body made when they can take a bioidentical hormone that is chemically structured like their own hormone. Big Pharma can't make a fortune off of the biodentical hormone because it cannot be patented, so they want to create more customers by taking away a good compounded medication that helps so many. Shame on the FDA!