I had a hysterectomy when I was 45 years old and was placed on synthetic premerin for about 14 years. When I stopped using this (doctor's orders), my system went nuts until I heard about hormone replacement therapy and found a doctor who could treat me. This made such a great change in my life. I am 81 years old and feel wonderful and am told I look 50. It would be a crime if we were unable to obtain this now.