It completely changed my life. Before using these, I was on sleep meds and other medications for joint pain, water retention, etc. I had no energy and was unable to sleep more than 1 or 2 hours at night. I could not focus on my job and it was affecting my productivity and my family life. Traditional meds helped me some, but each came with its own series of side effects. Sometimes, as bad as the original issue. I felt like a zombie for two or three years, and my doctor was only happy to add one more prescription every time a new symptom came up. Compound hormone replacement gave me my life back. Those of us who use it usually have tried every other traditional method with no success. We understand the risks, and to me the risk is totally worth it. This should be part of the RIGHT TO TRY policy. We pay from our pocket.