Instead of the one size fits all pharmaceutical dosage for estrace and progestin, the bioidentical HRT has been designed to fit the levels of estrogen and progesterone my body needs. The amount can be adjusted to maintain the levels that work best for me without side effects. The bioidentical works in conjunction with the synthroid medication. The pharmaceutical dosage caused loss of hair, dark skin pigmentation over the lips and on the knees, ringing in the ears, thyroid nodules developed and irritability/mood changes. After undergoing a recent DEXA scan, the gynecologist recommended I remain on the bioidentical hormones as the tests showed the density has been stable for several years with no new loss of bone. The gynecologist is not the doctor who prescribes the HRT but supports my doctors decision.