In November 2019, I switched from oral Estradial to an estriol compound. I was skeptical from the start. In fact, I was prepared for the bioidentical hormones to not be as effective as the "real" ones. But, I was motivated to stop using the oral estrogen because it passes through the liver and therefore is more toxic to the body. It took about two months for me to get the right dose of the compounded estrogens and when I did, it seemed to work even better than the estradial to prevent nights sweats, clear my mind of fog, and help my skin feel soft and supple. I would be really upset if I had to go back to a more toxic version of estrogen because the FDA did not allow compound pharmacies to make products that do not pass through the liver on the way to delivering their benefits.