In my late 30's I had a massive change in many of my hormones when I entered peri-menopause. I became weak, had hair loss and foggy cognitively. I was misdiagnosed a few times. Once I received specialized testing by my physician, it was identified the need for a specific dose of estrogen/progesterone combination that is natural and not synthetic. One dose does not fits all! I had to find the best for my well-being and did. I am now 60 and still on my HRT. I get regular checks on the levels related to my health and with compounded I can get it adjusted as needed. This is a personalize approach to my health and body. Please do not take this right away from us.