In 2014 I had a total huptervef my, I began to have strength at the gym overall fatigue my wrinkles, etc. If you are missing even one hormone it affects you I have always overcome weight 135 & 5' 10 1/2". this problem given me badly the hormone that your body produces. It is necessary for every system in your body. these hormones are is not as necessary as blood, your heart, etc.