I've been taking cBHT for for than 12 years. I'm 64. When I started, I studied the down side and saw little. Years ago, I did have a learning curve while it was figured out the correct dosage. I sleep a solid 8 hours and wake up refreshed. Before taking them, I had less energy, thinning lips, more obvious wrinkles, was getting little sleep and was very aware of my foggy brain and lack of inspiration and motivation. I had backed off writing, singing, learning, laughing and more. Now, I am my over achieving self...with practical allowances for aging, of course. I noticed differences in many ways, bowels, skin, lip fullness, sexual drive, energy, and overall health. If I was stuck on a deserted island and could have nothing else, I'd choose my hormones. Everything else will fall into place. I'm not without normal aging and yes, it would be nice to be younger. But, I am convinced that it would be felt much more without my compounded hormones.