I went into early menopause and had zero estrogen in my body! After weeks of sweating, sleeplessness, loss of appetite, and not being able to touch anything made of metal, plus anxiety and hyperventilation, I was ready to jump off a roof. Luckily my doctor started me on the Hormone Replacement Patch and 100 MG of progesterone. I now understand that when I start to feel that way we check my estrogen levels. Then we correct me! I also use testosterone cream. Without HRT I probably would have killed myself. HRT saved my life.