I was taking oral estrogen. I have PCOS. I went to a new doctor because my old doctor retired. My new doctor put me on bi-est compound cream because she wanted to avoid blood clots, then I had a hysterectomy. She kept me on the bi-est cream that I rub in my arm every day. So far, so good. I do not have medical insurance. I pay $36 a month for compounded bi -est. We can afford the compound made at Willis Brothers. We could not afford $130 a month gel from another pharmacy. I hope I can continue to buy bi-est cream.