I was initially given Premarin, the synthetic hormone that is made from horse urine and it put me at risk of an allergic reaction because it is on the list of things I tested positive for. I was happy to hear there was an alternative for this with the naturally compounded estriol, which is natural within my body but I don't produce enough of it. I have medical personal doctor advised reasons for needing use of this estrogen cream beyond menopause. I feel comfortable putting this in my body and not comfortable putting synthetic compounds in my body! It is interesting that this natural compounded estriol is not covered by insurance, but the synthetic brand Premarin is, despite it costing 3-4 times more. I choose to personally pay for my estriol. That is a whole other topic that this lower cost alternative should be covered.