I was in my mid-30's when I had to have a full hysterectomy. At that time they didn't have hormone replacement cream. I took a small dose of estrogen. A few years went by and I felt like I was losing myself. I was depressed, I gained weight, and I didn't have any energy. I didn't like my husband and I didn't like my kids. I went in to see my doctor and he said you know they have come out with hormone replacement compounds. Let's check your hormone level by running blood samples and see where you're at. My levels came back and everything was at a zero. He started me on my hormone replacement cream Within four weeks. I felt like a totally new person. This is something women even men cannot live without. I am now 53 years old and I don't know where I'd be without my hormones. I don't know if the FDA group that makes these decisions are a bunch of young people that just feel wonderful or if it's a bunch of men. I don't know, but they need to live with a woman 24/7 that has no hormones. They would be pleading with somebody to give them their replacement cream.