I was having typical post-menopausal symptoms that were very unpleasant. I DID NOT want to take synthetic hormones comprised of horse pee and possibly worse ingredients. I prefer to take no medications at all if possible, but the compounded medications don't contain those substances and are more natural. They have been working very well for me and I don't want to go without them even though insurance won't cover them. I'm willing to pay out of pocket for them because I feel they are safer and I don't want to add to Big Pharmaceutical companies bottom line.