I've suffered from hormone imbalances since I was 16. I developed every side effect listed from synthetic hormones. Without replacements, I had severe loss of memory, wild mood swings, debilitating hot flashes and night sweats and severe brain fog with no energy. I told my husband if I got hit by a semi, I wouldn't care because that was not living. I was just existing. Once I finally found a competent set of bioidentical hormone replacement doctors, everything smoothed out. It's like I'm 30 again instead of 62. I have NEVER had a negative side effect from compounded hormones. In fact, they cleared up a problem I had in my left breast that I swear was caused by synthetic hormones. Take away my compound hormones and I will be a dysfunctional zombie again within three days. That's all it takes.