I've been using the compound HRT for MANY years. I started with the troche, but the small private pharmacy in Leavenworth closed. My OBGYN suggested the vaginal cream for its lower dosage and personal balance. (I had to find a compound pharmacy in Kansas City). I feel it's kept me physically the same as I was before menopause, in ALL respects. I feel good, and most notably, my skin is moist and young. My body has not 'dried up', as they say. I'm now 71. My doctor recommended I cut back to just 1/2GM to keep the dosage even safer. I have never had any side effects or problems with this RX...being compounded just for me. Whenever I get the chance and the subject comes up with younger women, I highly recommend this type of HRT from the start, rather than suffering through testing other tablet type solutions. Even a few times when insurance wouldn't cover it, we gladly paid out of pocket...it's priceless! It just logically makes sense to be created individually for each woman, than guessing what 'might' work for all.