I've been using progesterone cream and Biest drops for six years. It's changed my life dramatically. I take an extremely small dose - just enough to ward off the negative affects of menopause. By using cream and drops, I can increase or decrease the dosage according to my symptoms. Cream and drops are also much easier on my liver. My sleep dramatically improved, eliminated middle of the night hot flashes and has balanced my mood. I feel at ease using compounded natural hormones. I don't want to use synthetic medication. I have to pay out of pocket and it's absolutely worth it.