I take vaginal estriol once a week. I receive this from a compounding pharmacy in a 1 mg dose. Estrogen is made from animal waste (horse urine). I do not wish to use this substance and prefer a more naturally derived, less strong estrogen replacement therapy. Estriol has been excellent for me, with greatly improved urine flow (normal, no leakage) and greatly improved vaginal prolapse levels.
Many prescribed, approved drugs in the United States cause death and extreme adverse reaction, yet are approved for use.
In the case of hormone replacement therapy, I hope very much my choice of medication and therapy is not curtailed because major drug companies are lobbying for their own self-interest. There is no lobby for more natural medicines and compounding pharmacies, but I hope you can create one.