I take liothyronine compounded for slow release instead of synthroid because it relives symptoms of hypothyroidism that synthroid could not, but I tried synthroid for years. Compounded T3 helps relive constipation, always feeling cold, hair growth, skin dryness, energy levels and easy weight gain. I have researched this topic and it seems some people have trouble converting t4 to t3 which is the active type of the hormone for metabolism. Bypassing t4, synthroid, and going directly to t3 is beneficial for me.