I suffered terribly from sleep deprivation when I entered peri-menopause . I had no REM sleep for 18 months and had developed all sort of psychological symptoms. I started bio-identical HRT and was perfectly normal two weeks after I began. I have been on HRT for 32 years and am 79. I have the bone density of a 28 year old, 0.2 T-score and 2.8 Z score. I have 0 calcium score i.e. no plaque, no atherosclerosis. I have no illnesses and only take thyroid and HRT with prescriptions. I physically present more like a 65 year old than a 79 year old.