I started with Progesterone only at 44. I was able to sleep and not feel so irritable prior to my period. I'm now 65 and don't want to think of life without my hormones. My last bone density was really good and my physician said the hormones definitely made a difference, since I'm at risk for osteoporosis. I have risk factors such as being petite and 111 lbs and having Hashimotos's Thyroiditis. These compounded hormones are vital to my well being.