I started with a synthetic HRT from my doctor at the time. I NEVER felt good! Then I found out about the compounded form from a local pharmacy. Wow, what a godsend! I was back to my old self right away! My doctor now says my health numbers are fantastic for a 67 year old female and will live along time to come. It is all due to this type of hormone I have been taking since 1999. I will, be very mad if the FDA does away with this. As women, we have to be able to do what is best for ourselves and NOT be controlled by some FDA official that is male and has no clue of how these compounded HRT's help us every day to be healthier and better people.